Rebel Medicine Overview
Rebel Medicine is a preclinical-stage company developing non-opioid solutions for acute pain management.
Contact Information
Address: 630 S Komas Dr #300
Salt Lake City, UT
URL: rebelmedicine.com
Rebel Medicine is a preclinical-stage company developing non-opioid solutions for acute pain management.
Address: 630 S Komas Dr #300
Salt Lake City, UT
URL: rebelmedicine.com
Pain after surgery is most severe during the first 72 hours and effective pain management during this time is essential for patient recovery and satisfaction. Currently, opioid-based medications are the mainstay of acute postoperative pain management; however, opioid use is associated with a variety of adverse events such as addiction, respiratory depression, cognitive impairment, nausea, constipation, and death. These opioid-related adverse events after surgery can prolong hospital stay after surgery by 3 days and increase overall cost-of-care by $5000. Additionally, opioid use disorders contribute a substantial financial burden to society with an estimated cost of $78 billion per year to the US health care system, workplace loss of productivity costs estimated at a total of $25.5 billion per year, and criminal justice costs estimated at a total of $5.1 billion per year.
Our technology is a novel prolonged release local anesthetic formulation of bupivacaine. The technology consists of local anesthetic-loaded lipid matrix particles that are entrapped in a hyaluronic acid hydrogel. Bupivacaine slowly diffuses out of the tristearin matrix, providing prolonged analgesia. The hydrogel component of the system increases the viscosity of the formulation which serves to keep the bupivacaine-loaded matrix particles at the site of application. Additionally, it serves to temporarily shield the drug-loaded particles from the in vivo environment, slowing the degradation and removal of the drug load from the application site and allowing for the prolonged release of bupivacaine to occur. This formulation is intended for use in surgical settings to provide post-surgical analgesia for up to 72 hours. The formulation has versatility in use and can be applied directly to the surgical site at the conclusion of surgery or it can be injected to target a specific nerve to completely anesthetize the region of tissue the nerve innervates (peripheral nerve block). It will be intuitively used by the clinician end-user and will be packaged in ready-to-use, pre-filled syringes.